Endocrine Abstracts

Introduction Carcinoid heart disease most frequently involves the tricuspid or, more rarely, the pulmonary valve and presents with right heart failure as 5-HT is metabolized by the lung. Left-sided valve involvement is quite rare. We describe our experience of 3 patients presenting with heart failure secondary to carcinoid heart disease affecting all four cardiac valves. There are only four previous isolated case reports in the literature. Methods All th...

Background: The PCSK9 inhibitors (PCSKi), evolocumab and alirocumab, were approved by NICE in 2016, and have since proved to be efficacious in lowering LDL-C. Yet little is known about their long-term adverse effects. Genetic studies have shown patients with PCSK9 loss-of-function variants are at increased risk of T2DM. Similarly, analyses of an adverse event database found increased reports of PCSK9i-related hyperglycaemia. Meta-analyses have suggested that P...

Introduction: The newly proposed RCOG guidelines suggests dose increment of thyroxine based on prenatal thyroxine doses. The aim of our retrospective audit was to assess if the aetiology of hypothyroidism (and dose of thyroxine) prenatally could help predict the need for dose increment during pregnancy.Methods: n=100. Local guidelines advised maintaining TSH <2.5 throughout pregnancy. Outcomes of thyroxine a...

Background: There is a well-documented relationship between lithium exposure and thyroid dysfunction via multiple mechanisms. Lithium is commonly associated with goitre, hypothyroidism, and subclinical hypothyroidism. Lithium-induced autoimmune hyperthyroidism is rare and poorly understood. We report a case of autoimmune thyroiditis, Graves’ disease (GD), in a patient with longstanding primary hypothyroidism believed to be induced by Lithium.<p class=...

Background: Granulomatous mastitis (GM) is a rare inflammatory condition of the breast typically affecting women during postpartum period. GM can mimic inflammatory breast cancer and only be reliably distinguished through histopathology. While there is no generally accepted treatment for GM, therapeutic options include - antibiotics, wide surgical excision, and corticosteroids.Clinical Case: A 54-year-old female presented to her family physician with wit...

Introduction: Pseudohypoparathyroidism (PHP) refers to a group of rare sporadic or inherited disorders characterized by parathyroid hormone (PTH) resistance. We report a case of PHP with phenotypical expression and multiple hormonal resistance.Case description: We report a 26-year-old lady who presented to us after a fall, with history of recurrent seizures since 12 years of age. There was a history of oligomennorhoea. Physical examination revealed round...

Patients with acromegaly (PWA) experience higher rates of falls and fall-related injuries than age-matched Canadian adults. Previous studies of standing balance revealed increased sway in PWA compared to healthy controls but failed to control for the effects of the pituitary adenoma. Therefore, the aim of the present study was to determine if acromegaly influenced the neuromuscular control of standing balance. Bipedal standing balance was evaluated in PWA (n=13) in bi...

Acromegaly triggers, and is associated with, peripheral nervous system modifications and joint degenerations, which are considered to impact the walking balance of patients with acromegaly (PWA). Therefore, to better understand if these systemic degenerations impact the transitory adaptations in locomotor patterns of these patients, this study aims to establish the walking balance deficits of PWA. Walking balance was evaluated in PWA (n=8) in biochemical remission and...

Acromegaly, characterized by growth hormone excess, adversely affects the patients’ musculoskeletal and neural systems, consequently impairing physical function. Previous studies have noted walking impairments in patients with acromegaly (PWA). This study aimed to characterize the kinematic and kinetic changes during walking in PWA. Kinematics and kinetics of walking were evaluated in PWA (n=8) in biochemical remission and a control group of patients with non-fun...

Background: Childhood obesity is associated with multitude of co-morbidities. Idiopathic intracranial hypertension (IIH) is one of the less common co-morbidities in children and young people. Severe migraine has been postulated as a further association. We report our experience of using topiramate for managing obesity associated IIH and severe persistent migraine.Cases: Case One: A 12 year old boy was referred with morbid obesity, systemic hypertension a...